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Recombination and lineage-specific mutations linked to the emergence of SARS-CoV-2

6 Aug 2021

Abstract excerpt

BACKGROUND: The emergence of SARS-CoV-2 underscores the need to better understand the evolutionary processes that drive the emergence and adaptation of zoonotic viruses in humans. In the betacoronavirus genus, which also includes SARS-CoV and MERS-CoV, recombination frequently encompasses the receptor binding domain (RBD) of the Spike protein, which is responsible for viral binding to host cell receptors. In this...

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PMID: 34362430
DOI: 10.1186/s13073-021-00943-6

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