Article

SARS-CoV-2 spike glycoprotein hotspots for RNA recombination provide insight into the probable human origin of the PRRA polybasic furin insert

2023-06-26

Abstract excerpt

The SARS-CoV-2 origin is linked to the acquisition by its closest progenitor of a positive insert in the spike glycoprotein. Itwas the PRRA polybasic motif atthe furin cleavage site. This furin recognition motif has no analogy with other B-lineage beta-coronaviruses, nor with the known Laos bat closest relatives. An hypothesis for probable PRRA human origin includes recombination between a SARS-CoV-2 progenitor ge...

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Literature Corpus work: 82a456d5-ed81-5303-b407-41692defb7e8
DOI: 10.21203/rs.3.rs-3098219/v1

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