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Article

Genomic determinants of Furin cleavage in diverse European SARS-related bat coronaviruses

30 May 2022

Abstract excerpt

The furin cleavage site (FCS) in SARS-CoV-2 is unique within the Severe acute respiratory syndrome-related coronavirus (SrC) species. We re-assessed diverse SrC from European horseshoe bats and analyzed the spike-encoding genomic region harboring the FCS in SARS-CoV-2. We reveal molecular features in SrC such as purine richness and RNA secondary structures that resemble those required for FCS acquisition in avian...

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PMID: 35637279
DOI: 10.1038/s42003-022-03421-w

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