Article
SARS-CoV-2 Omicron XBB lineage spike structures, conformations, antigenicity, and receptor recognition.
Molecular cell - 25 Jul 2024
Zhang Qianyi E, Lindenberger Jared, Parsons Ruth J, Thakur Bhishem, Parks Rob, Park Chan Soo, Huang Xiao, Sammour Salam, Janowska Katarzyna, Spence Taylor N, Edwards Robert J, Martin Mitchell, Williams Wilton B, Gobeil Sophie, Montefiori David C, Korber Bette, Saunders Kevin O, Haynes Barton F, Henderson Rory, Acharya Priyamvada
Abstract excerpt
A recombinant lineage of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant, named XBB, appeared in late 2022 and evolved descendants that successively swept local and global populations. XBB lineage members were noted for their improved immune evasion and transmissibility. Here, we determine cryoelectron microscopy (cryo-EM) structures of XBB.1.5, XBB.1.16, EG.5, and EG.5.1 spike...
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