Article

Analysis of allelic series with transcriptomic phenotypes

2017-10-29

Abstract excerpt

Although transcriptomes have recently been used to perform epistasis analyses, they are not yet used to study intragenic function/structure relationships. We developed a theoretical framework to study allelic series using transcriptomic phenotypes. As a proof-of-concept, we apply our methods to an allelic series of dpy-22 , a highly pleiotropic Caenorhabditis elegans gene orthologous to the human gene MED12 , w...

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Literature Corpus work: 36aa4b3f-5650-5cb1-bcf1-05028270006d
DOI: 10.1101/210724

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