Article
Genome-wide modeling of complex phenotypes in Caenorhabditis elegans and Drosophila melanogaster.
BMC genomics - 28 Aug 2013
De Supriyo, Zhang Yongqing, Wolkow Catherine A, Zou Sige, Goldberg Ilya, Becker Kevin G
Abstract excerpt
BACKGROUND: The genetic and molecular basis for many intermediate and end stage phenotypes in model systems such as C. elegans and D. melanogaster has long been known to involve pleiotropic effects and complex multigenic interactions. Gene sets are groups of genes that contribute to multiple biological or molecular phenomena. They have been used in the analysis of large molecular datasets such as microarray data,...
Topics
- Animals
- Caenorhabditis elegans
- Databases, Genetic
- Drosophila melanogaster
- Gene Ontology
- Genes, Helminth
- Genes, Insect
- Genetic Pleiotropy
- Genome
- Models, Genetic
- Oligonucleotide Array Sequence Analysis
- Phenotype
- Principal Component Analysis
- Transcriptome