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Article

High-throughput Production of Diverse Xenobiotic Metabolites with P450-transduced Huh7 Hepatoma Cell Lines

2022-03-14

Abstract excerpt

Precision medicine requires methods to assess drug metabolism and distribution, including the identification of known and undocumented drug and chemical exposures as well as their metabolites. Recent work demonstrated high-throughput generation of xenobiotic metabolites with human liver S-9 fractions and detection in human plasma and urine. Here, we developed a panel of lentivirally transduced human hepatoma cell...

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Literature Corpus work
36a5f185-1bf7-5010-9a62-a8be6b1c55e0
DOI
10.1101/2022.03.12.484071
Open publication

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High-throughput Production of Diverse Xenobiotic Metabolites with P450-transduced Huh7 Hepatoma Cell LinesDOI 10.1101/2022.03.12.484071
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