Article
A targeted lipidomics workflow for high-throughput phenotyping and mechanism-based in vitro hepatotoxicity studies.
Toxicology in vitro : an international journal published in association with BIBRA - 1 Dec 2026
Yen Tzu-Hsin, Negi Chander K, Sakolish Courtney, Baker Erin S, Rusyn Ivan
Abstract excerpt
Animal-based toxicity testing is limited in throughput and mechanistic characterization, underscoring the need for cell-based approaches. Incorporating molecular readouts, such as lipidomics, can enhance the translational relevance of cell-based assays. Because untargeted lipidomic analyses are time-consuming and can require large sample volumes, a targeted workflow was used in this study to characterize...
Read the complete abstract on PubMedTopics
- Animals
- Lipidomics
- Humans
- Hepatocytes
- Dogs
- Rats
- Cells, Cultured