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Article

Profiles of β-Amyloid Peptides and Key Secretases in Brain Autopsy Samples Differ with Sex and APOE ε4 Status: Impact for Risk and Progression of Alzheimer Disease.

Neuroscience - 1 Mar 2018

Nyarko Jennifer N K, Quartey Maa O, Pennington Paul R, Heistad Ryan M, Dea Doris, Poirier Judes, Baker Glen B, Mousseau Darrell D

Abstract excerpt

The APOE ε4 allele was originally reported to contribute to risk of Alzheimer's disease (AD) in women, yet male and female AD patient-derived data are routinely pooled. Histopathological hallmarks of AD include neurofibrillary tangles centered on hyperphosphorylated Tau and plaques composed of the β-amyloid (Aβ) peptide that is derived by sequential secretase-mediated cleavage of the Amyloid Protein Precursor...

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Source

Identifiers

PMID: 29331531
DOI: 10.1016/j.neuroscience.2018.01.005

Genes

APOE
APP
ADAM10
BACE1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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