Associations Between Female Sex, Sarcomere Variants, and Clinical Outcomes in Hypertrophic Cardiomyopathy.

doi:10.1161/CIRCGEN.120.003062

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Article

Associations Between Female Sex, Sarcomere Variants, and Clinical Outcomes in Hypertrophic Cardiomyopathy.

Circulation. Genomic and precision medicine - 1 Feb 2021

Lakdawala Neal K, Olivotto Iacopo, Day Sharlene M, Han Larry, Ashley Euan A, Michels Michelle, Ingles Jodie, Semsarian Christopher, Jacoby Daniel, Jefferies John L, Colan Steven D, Pereira Alexandre C, Rossano Joseph W, Wittekind Sam, Ware James S, Saberi Sara, Helms Adam S, Cirino Allison L, Leinwand Leslie A, Seidman Christine E, Ho Carolyn Y

Abstract excerpt

BACKGROUND: The impact of sex on phenotypic expression in hypertrophic cardiomyopathy (HCM) has not been well characterized in genotyped cohorts. METHODS: Retrospective cohort study from an international registry of patients receiving care at experienced HCM centers. Sex-based differences in baseline characteristics and clinical outcomes were assessed. RESULTS: Of 5873 patients (3788 genotyped), 2226 (37.9%) were...

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PMID: 33284039
DOI: 10.1161/CIRCGEN.120.003062

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