MRI-derived wall thickness heterogeneity in hypertrophic cardiomyopathy and in carriers of sarcomeric gene mutations.

doi:10.1093/ehjci/jeag086

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Article

MRI-derived wall thickness heterogeneity in hypertrophic cardiomyopathy and in carriers of sarcomeric gene mutations.

European heart journal. Cardiovascular Imaging - 30 Jun 2026

Aquaro Giovanni Donato, Licordari Roberto, Todiere Giancarlo, Ianni Umberto, De Gori Carmelo, Merlo Marco, Barison Andrea, De Luca Antonio, Grigoratos Crysanthos, Raimondi Francesca, Ait-Ali Lamia, Festa Pierluigi, Negri Francesco, Bianco Francesco, Ricci Fabrizio, Botto Nicoletta, Taddei Lapo, Alberti Mattia, Italiano Andrea, Gargani Luna, Faggioni Lorenzo, Cioni Dania, Lencioni Riccardo, Emdin Michele, Neri Emanuele, Sinagra Gianfranco, De Caterina Raffaele, Di Bella Gianluca

Abstract excerpt

AIMS: Hypertrophic cardiomyopathy (HCM) shows variable left ventricular hypertrophy, yet current diagnostic criteria rely on absolute wall thickness (WT) cut-offs that may miss early or subtle phenotypes, particularly in sarcomere mutation carriers. OBJECTIVES: To determine whether wall thickness standard deviation (WTSD), reflecting WT heterogeneity, improves identification of HCM and mutation carriers. METHODS...

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Identifiers

PMID: 41923453
DOI: 10.1093/ehjci/jeag086

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