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Stochastic asymmetric repartition of lytic machinery in dividing CD8 <sup>+</sup> T cells generates heterogeneous killing behavior

2020-09-08

Abstract excerpt

Cytotoxic immune cells are endowed with a high degree of heterogeneity in their lytic function, but how this heterogeneity is generated is still an open question. We therefore investigated if human CD8 + T cells could segregate their lytic components during telophase, using imaging flow cytometry, confocal microscopy and live cell imaging. We show that CD107a + -intracellular vesicles, perforin and granzyme B un...

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Literature Corpus work
360efe2c-2132-57f1-9e77-763d9bef3fb9
DOI
10.1101/2020.09.08.287029
Open publication

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Stochastic asymmetric repartition of lytic machinery in dividing CD8 <sup>+</sup> T cells generates heterogeneous killing behaviorDOI 10.1101/2020.09.08.287029
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