Article
Division-linked differentiation can account for CD8+ T-cell phenotype in vivo.
European journal of immunology - 1 Jan 2009
Schlub Timothy E, Venturi Vanessa, Kedzierska Katherine, Wellard Cameron, Doherty Peter C, Turner Stephen J, Ribeiro Ruy M, Hodgkin Philip D, Davenport Miles P
Abstract excerpt
The CD8(+) T-cell response to infection involves a large initial expansion in the numbers of responding cells, accompanied by differentiation of these cells. Expression of the adhesion molecule CD62L is high on naïve cells and rapidly downregulated on the surface of the majority (approximately 90...
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