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Campylobacter phages use hypermutable polyG tracts to create phenotypic diversity and evade bacterial resistance.

Cell reports - 8 Jun 2021

Sørensen Martine C Holst, Vitt Amira, Neve Horst, Soverini Matteo, Ahern Stephen James, Klumpp Jochen, Brøndsted Lone

Abstract excerpt

Phase variation is a common mechanism for creating phenotypic heterogeneity of surface structures in bacteria important for niche adaptation. In Campylobacter, phase variation occurs by random variation in hypermutable homonucleotide 7-11 G (polyG) tracts. To elucidate how phages adapt to phase-variable hosts, we study Fletchervirus phages infecting Campylobacter dependent on a phase-variable receptor. Our data...

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PMID: 34107245
DOI: 10.1016/j.celrep.2021.109214

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