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Stabilizing genetically unstable simple sequence repeats in the <i>Campylobacter jejuni</i> genome by multiplex genome editing: a reliable approach for delineating multiple phase-variable genes

2021-05-14

Abstract excerpt

Hypermutability of simple sequence repeats (SSR) through DNA slippage is a major mechanism of phase variation in Campylobacter jejuni. The presence of multiple SSR-mediated phase-variable genes encoding enzymes that modify surface structures, including capsular polysaccharide (CPS) and lipooligosaccharide (LOS), generates high levels of structural variants within bacterial populations, thereby promoting adaptatio...

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Literature Corpus work
821aee03-1e37-5354-8d07-52e91b6e1803
DOI
10.1101/2021.05.14.444138
Open publication

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Stabilizing genetically unstable simple sequence repeats in the <i>Campylobacter jejuni</i> genome by multiplex genome editing: a reliable approach for delineating multiple phase-variable genesDOI 10.1101/2021.05.14.444138
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