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Article

IL1R1+ cancer-associated fibroblasts drive tumor development and immunosuppression in colorectal cancer

17 Jul 2023

Abstract excerpt

Abstract Fibroblasts have a considerable functional and molecular heterogeneity and can play various roles in the tumor microenvironment. Here we identify a pro-tumorigenic IL1R1+, IL-1-high-signaling subtype of fibroblasts, using multiple colorectal cancer (CRC) patient single cell sequencing datasets. This subtype of fibroblasts is linked to T cell and macrophage suppression and leads to increased cancer cell...

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PMID: 37460545
DOI: 10.1038/s41467-023-39953-w

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