Article

A combination of major histocompatibility complex (MHC) I overexpression and type I interferon induce mitochondrial dysfunction in human skeletal myoblasts

2024-04-11

Abstract excerpt

<h4>ABSTRACT</h4> The overexpression of major histocompatibility complex (MHC) I on the surface of muscle fibres is a characteristic hallmark of the idiopathic inflammatory myopathies (IIMs), collectively termed myositis. Alongside MHC-I overexpression, sub-types of myositis, display a distinct type I interferon (IFN) signature. This study examined the combinational effects of elevated MHC-I and type I IFNs (IFNα...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 35aa5791-eb64-5ad8-9de5-c12baf98835f
DOI: 10.1101/2024.04.10.588847

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A combination of major histocompatibility complex (MHC) I overexpression and type I interferon induce mitochondrial dysfunction in human skeletal myoblastsDOI 10.1101/2024.04.10.588847Read

The Emerging Role of Mitochondrial Dysfunction in the Pathogenesis of Idiopathic Inflammatory MyopathiesSemantic proximity Read

Mitochondrial dysfunction and role of harakiri in the pathogenesis of myositisSemantic proximity Read

Major Histocompatibility Complex (MHC) I-induced Endoplasmic Reticulum (ER) Stress mediates the secretion of pro-inflammatory muscle-derived cytokinesSemantic proximity Read

Eukarion-134 attenuates endoplasmic reticulum stress-induced mitochondrial dysfunction in human skeletal muscle cellsSemantic proximity Read

Mitochondrial instability contributes to IFN-driven heart diseaseSemantic proximity Read

Antigen-driven T cell-macrophage interactions mediate the interface between innate and adaptive immunity in histidyl-tRNA synthetase-induced myositisSemantic proximity Read

Anti-mitochondrial antibody-positive myositis: A systematic review of 123 casesSemantic proximity Read

Hypoxia triggers IFN-I production in muscle: Implications in dermatomyositisSemantic proximity Read

Experimental myositis: an optimised version of C-protein-induced myositisSemantic proximity Read

Inflammatory myopathy associated with anti-mitochondrial antibodies: A distinct phenotype with cardiac involvement.Semantic proximity Read

Engineering of human myotubes toward a mature metabolic and contractile phenotypeSemantic proximity Read

Clinical characterization and molecular mechanisms of statin myopathy.Semantic proximity Read