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Hypoxia triggers IFN-I production in muscle: Implications in dermatomyositis

11 Aug 2017

Abstract excerpt

Dermatomyositis is an inflammatory myopathy characterized by symmetrical proximal muscle weakness and skin changes. Muscle biopsy hallmarks include perifascicular atrophy, loss of intramuscular capillaries, perivascular and perimysial inflammation and the overexpression of IFN-inducible genes. Among them, the retinoic-acid inducible gene 1 (RIG-I) is specifically overexpressed in perifascicular areas of...

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PMID: 28819164
DOI: 10.1038/s41598-017-09309-8

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