Article

Cross-Phenotype Plasma Proteomics Reveals Molecular Heterogeneity in Neovascular AMD

2026-06-02

Abstract excerpt

Age-related macular degeneration (AMD) shows substantial clinical heterogeneity that remains unexplained despite extensive genetic and clinical characterization. We evaluated whether proteomic stratification could provide insight beyond clinical phenotype and genetic risk. We performed 384-plex plasma proteomics in a cohort of 215 individuals, including patients with early and late neovascular AMD, other complemen...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 35a9d575-f587-5e0a-a3c5-439928f8a54a
DOI: 10.64898/2026.05.26.26354036

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cross-Phenotype Plasma Proteomics Reveals Molecular Heterogeneity in Neovascular AMDDOI 10.64898/2026.05.26.26354036Read

Systemic Blood Proteome Patterns Reflect Disease Phenotypes in Neovascular Age-Related Macular Degeneration.Semantic proximity Read

A proteogenomic signature of age-related macular degeneration in bloodSemantic proximity Read

A Proteogenomic Signature of Age-related Macular Degeneration in BloodSemantic proximity Read

Proteomics-based identification and validation of novel plasma biomarkers phospholipid transfer protein and mannan-binding lectin serine protease-1 in age-related macular degeneration.Semantic proximity Read

Recent Advances in Proteomic-based Approaches to Study Age-related Macular Degeneration: A Systematic ReviewSemantic proximity Read

Systems-level analysis of age-related macular degeneration reveals global biomarkers and phenotype-specific functional networksSemantic proximity Read

Proteomic Profiles in Advanced Age-Related Macular Degeneration Using an Aptamer-Based Proteomic TechnologySemantic proximity Read

Proteome-wide Mendelian randomization study implicates inflammaging biomarkers in retinal vasculature, cardiometabolic diseases and longevitySemantic proximity Read

Analysis of the Aqueous Humor Proteome in Patients With Age-Related Macular DegenerationSemantic proximity Read

Integrative genomic and proteomic analyses identify candidate genetic loci and genetically supported proteins in age-related macular degenerationSemantic proximity Read

Identification of cellular and molecular risk signatures for progression to late-stage age-related macular degeneration using the 9-step Minnesota Grading SystemSemantic proximity Read

A Proteomic Profile of the Ocular Phenome: Systemic Signatures, Predictive Value, and Causal Insights Across 131 Ocular Diseases and TraitsSemantic proximity Read