Article

Identification of cellular and molecular risk signatures for progression to late-stage age-related macular degeneration using the 9-step Minnesota Grading System

2025-07-16

Abstract excerpt

<h4>ABSTRACT</h4> Age-related macular degeneration (AMD) is a complex multifactorial disease, and the molecular mechanisms underpinning the progression of intermediate AMD to geographic atrophy are not fully understood. To better understand mechanisms driving progression, we performed bulk RNA sequencing on dissected macular and peripheral RPE/choroid and neural retina tissue from postmortem human eyes graded usi...

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Literature Corpus work: 5af7459a-42e4-51fe-8354-3dceba6dc967
DOI: 10.1101/2025.07.10.664209

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