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Article

Systemic Blood Proteome Patterns Reflect Disease Phenotypes in Neovascular Age-Related Macular Degeneration.

International journal of molecular sciences - 19 Jun 2023

Künzel Steffen E, Flesch Leonie T M, Frentzel Dominik P, Knecht Vitus A, Rübsam Anne, Dreher Felix, Schütte Moritz, Dubrac Alexandre, Lange Bodo, Yaspo Marie-Laure, Lehrach Hans, Joussen Antonia M, Zeitz Oliver

Abstract excerpt

There is early evidence of extraocular systemic signals effecting function and morphology in neovascular age-related macular degeneration (nAMD). The prospective, cross-sectional BIOMAC study is an explorative investigation of peripheral blood proteome profiles and matched clinical features to uncover systemic determinacy in nAMD under anti-vascular endothelial growth factor intravitreal therapy (anti-VEGF IVT)....

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Identifiers

PMID: 37373474
DOI: 10.3390/ijms241210327
PMCID: PMC10299094

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