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An Engineered T7 RNA Polymerase for efficient co-transcriptional capping with reduced dsRNA byproducts in mRNA synthesis

2022-09-02

Abstract excerpt

Messenger RNA (mRNA) therapies have recently gained tremendous traction with the approval of mRNA vaccines for the prevention of SARS-CoV-2 infection. However, manufacturing challenges have complicated large scale mRNA production, which is necessary for the clinical viability of these therapies. Not only can the incorporation of the required 5’ 7-methylguanosine cap analog be inefficient and costly, in vitro trans...

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Identifiers and source

Literature Corpus work
359fe187-dfd6-5208-9dbb-064657124380
DOI
10.1101/2022.09.01.506264
Open publication

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An Engineered T7 RNA Polymerase for efficient co-transcriptional capping with reduced dsRNA byproducts in mRNA synthesisDOI 10.1101/2022.09.01.506264
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