Engineering Linear Cap-independent mRNA Vaccines with Intrinsic Adjuvanticity for Potent Cancer Immunotherapy

Abstract excerpt

<h4>ABSTRACT</h4> mRNA cancer vaccines have shown promising efficacy in early-phase clinical trials, but existing platforms struggle to boost antitumor efficacy without added cost or complexity. Here, we present a streamlined linear cap-independent RNA (LciRNA) cancer vaccine platform that achieves stable expression in vivo without 5’ capping or ribonucleotide modification, and innately stimulates immune respons...

Topics

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• CAR-T cell therapy research
• Circular RNAs in diseases
• Immunotherapy and Immune Responses
• RNA and protein synthesis mechanisms
• RNA Interference and Gene Delivery
• SARS-CoV-2 and COVID-19 Research
• Viral gastroenteritis research and epidemiology
• Virus-based gene therapy research

Identifiers and source

Literature Corpus work

7bb370cc-a335-5e05-8f08-2880aa8ff623

DOI

10.1101/2025.10.27.684966