Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effective Synthesis of mRNA during In Vitro Transcription with Fewer Impurities Produced.

Molecules (Basel, Switzerland) - 5 Oct 2024

He Wei, Geng Qi, Ji Guiying, Li Ji, Wang Dan, He Yucai, Jin Qiuheng, Ye Jianren

Abstract excerpt

The remarkable efficacy of COVID-19 vaccines has established mRNA as a highly promising biomedical technology. However, the adequate application of mRNA therapeutics necessitates additional measures to mitigate the inherent immunogenicity, which is predominantly caused by dsRNA. As a byproduct of the in vitro transcription of mRNA, dsRNA was reported to be originated through several distinct mechanisms, including...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to COVID-19
Share to COVID-19 Vaccines
Share to DNA-Directed RNA Polymerases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Promoter Regions, Genetic

Share to RNA, Double-Stranded

Share to SARS-CoV-2

Share to Transcription, Genetic

Share to Viral Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 39407643
DOI: 10.3390/molecules29194713
PMCID: PMC11477551

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effective Synthesis of mRNA during In Vitro Transcription with Fewer Impurities Produced.PMID 39407643Read ↗

An Engineered T7 RNA Polymerase for efficient co-transcriptional capping with reduced dsRNA byproducts in mRNA synthesisSemantic proximity Read ↗

Advancements of in vitro transcribed mRNA (IVT mRNA) to enable translation into the clinicsSemantic proximity Read ↗

Technological breakthroughs and advancements in the application of mRNA vaccines: a comprehensive exploration and future prospectsSemantic proximity Read ↗

The mRNA Vaccine Revolution: COVID-19 Has Launched the Future of VaccinologySemantic proximity Read ↗

Maximizing the productivity of co-transcriptional in vitro transcriptionSemantic proximity Read ↗

An Update on mRNA-Based Viral VaccinesSemantic proximity Read ↗

Minimizing dsRNA impurity generation through structure-function-guided directed evolution of T7 RNA polymerase.Semantic proximity Read ↗

Recent Advances in mRNA Vaccine DevelopmentSemantic proximity Read ↗

Enabling mRNA Therapeutics: Current Landscape and Challenges in ManufacturingSemantic proximity Read ↗

Prospects and Challenges in Developing mRNA Vaccines for Infectious Diseases and Oncogenic VirusesSemantic proximity Read ↗

From COVID-19 to Global Health: Challenges and Opportunities in mRNA Vaccine ProductionSemantic proximity Read ↗

The Importance of RNA-Based Vaccines in the Fight against COVID-19: An OverviewSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.