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Article

Mutations in the hminK gene cause long QT syndrome and suppress IKs function.

Nature genetics - 1 Nov 1997

Splawski I, Tristani-Firouzi M, Lehmann M H, Sanguinetti M C, Keating M T

Abstract excerpt

Ion-channel beta-subunits are ancillary proteins that co-assemble with alpha-subunits to modulate the gating kinetics and enhance stability of multimeric channel complexes. Despite their functional importance, dysfunction of potassium-channel beta-subunits has not been associated with disease. Recent physiological studies suggest that KCNE1 encodes beta-subunits (hminK) that co-assemble with KvLQT1 alpha-subunits...

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PMID: 9354802
DOI: 10.1038/ng1197-338

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Mutations in the hminK gene cause long QT syndrome and suppress IKs function.PMID 9354802Read ↗

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Dysfunctional potassium channel subunit interaction as a novel mechanism of long QT syndrome.Semantic proximity Read ↗

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