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Article

Functional Genome Analysis for Immune Cells Provides Clues for Stratification of Systemic Lupus Erythematosus.

Biomolecules - 25 Mar 2023

Fujio Keishi

Abstract excerpt

Systemic lupus erythematosus (SLE) is caused by a combination of genetic and environmental factors. Recently, analysis of a functional genome database of genetic polymorphisms and transcriptomic data from various immune cell subsets revealed the importance of the oxidative phosphorylation (OXPHOS) pathway in the pathogenesis of SLE. In particular, activation of the OXPHOS pathway is persistent in inactive SLE,...

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Share to Genetic Predisposition to Disease
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Identifiers

PMID: 37189338
DOI: 10.3390/biom13040591
PMCID: PMC10136231

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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