Article

Molecular Profiles of Matched Primary and Metastatic Tumor Samples Support a Linear Evolutionary Model of Breast Cancer

2019-06-12

Abstract excerpt

The interpretation of accumulating genomic data with respect to tumor evolution and cancer progression requires integrated models. We developed a computational approach that enables the construction of disease progression models using static sample data. Application to breast cancer data revealed a linear, branching evolutionary model with two distinct trajectories for malignant progression. Here, we used the prog...

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Literature Corpus work: 3576c30d-93ca-5225-8548-0c12196709e9
DOI: 10.1101/667303

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