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PARP16 protects against pathological cardiac remodelling by ADP-ribosylation-dependent inhibition of NFAT transcription factor

2026-03-31

Abstract excerpt

<h4>Summary</h4> Mono-ADP-ribosylation is a post-translational modification that regulates diverse cellular processes. PARP16 is an endoplasmic reticulum-associated mono-ADP-ribosyltransferase implicated in stress-response signalling; however, its role in cardiac remodelling and dysfunction has not been fully defined. Our results suggest that PARP16 expression was reduced in human heart failure samples. Deletion...

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Identifiers and source

Literature Corpus work
35393485-616e-52fd-b242-a900ec5522ce
DOI
10.64898/2026.03.30.715447
Open publication

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PARP16 protects against pathological cardiac remodelling by ADP-ribosylation-dependent inhibition of NFAT transcription factorDOI 10.64898/2026.03.30.715447
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