Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulation of Transcription Factor NFAT by ADP-Ribosylation

25 Feb 2008

Abstract excerpt

ADP-ribosylation is a reversible posttranslational modification mediated by poly-ADP-ribose polymerase (PARP). The results of recent studies demonstrate that ADP-ribosylation contributes to transcription regulation. Here, we report that transcription factor NFAT binds to and is ADP-ribosylated by PARP-1 in an activation-dependent manner. Mechanistically, ADP-ribosylation increases NFAT DNA binding. Functionally,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to PARP inhibition in cancer therapy
Share to Signaling Pathways in Disease
Share to Toxin Mechanisms and Immunotoxins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18299389
DOI: 10.1128/mcb.01746-07

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation of Transcription Factor NFAT by ADP-RibosylationPMID 18299389Read ↗

PARP1 Hinders Histone H2B Occupancy at the NFATc1 Promoter to Restrain Osteoclast DifferentiationSemantic proximity Read ↗

PARP16 protects against pathological cardiac remodelling by ADP-ribosylation-dependent inhibition of NFAT transcription factorSemantic proximity Read ↗

ADP-ribosylation from molecular mechanisms to therapeutic implicationsSemantic proximity Read ↗

ADP-ribosylation: An emerging direction for disease treatmentSemantic proximity Read ↗

ADP‐ribosyltransferases, an update on function and nomenclatureSemantic proximity Read ↗

Transcriptional regulation by Poly(ADP-ribose) polymerase-1 during T cell activationSemantic proximity Read ↗

Poly(ADP-ribosyl)ation of FOXP3 Protein Mediated by PARP-1 Protein Regulates the Function of Regulatory T CellsSemantic proximity Read ↗

The Role of PARPs in Inflammation—And Metabolic—Related Diseases: Molecular Mechanisms and BeyondSemantic proximity Read ↗

Caspase-dependent cleavage of the mono-ADP-ribosyltransferase ARTD10 interferes with its pro-apoptotic function.Semantic proximity Read ↗

c-Abl–Mediated Tyrosine Phosphorylation of PARP1 Is Crucial for Expression of Proinflammatory GenesSemantic proximity Read ↗

Poly(ADP-Ribose) Polymerases in Host-Pathogen Interactions, Inflammation, and ImmunitySemantic proximity Read ↗

Poly(ADP-ribosyl)ation in relation to cancer and autoimmune disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.