Article

Large-scale genetic analysis of age-related macular degeneration (AMD) drug targets highlights precision therapy opportunities for patients with high polygenic risk

2025-12-29

Abstract excerpt

<h4>Background</h4> In the past two decades, genetic studies have elucidated the contributions of key biological pathways to the pathogenesis of age-related macular degeneration (AMD), including complement activation, lipoprotein metabolism, angiogenesis, and extracellular matrix maintenance. Of these pathways, complement in particular has been observed to dominate the genetic architecture of AMD. Yet, clinical t...

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Literature Corpus work: 35174d95-56d4-5085-baf8-c4896cae30f5
DOI: 10.64898/2025.12.26.25343053

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