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Article

Estimating cumulative pathway effects on risk for age-related macular degeneration using mixed linear models.

BMC bioinformatics - 14 Oct 2015

Hall Jacob B, Cooke Bailey Jessica N, Hoffman Joshua D, Pericak-Vance Margaret A, Scott William K, Kovach Jaclyn L, Schwartz Stephen G, Agarwal Anita, Brantley Milam A, Haines Jonathan L, Bush William S

Abstract excerpt

BACKGROUND: Age-related macular degeneration (AMD) is the leading cause of irreversible visual loss in the elderly in developed countries and typically affects more than 10% of individuals over age 80. AMD has a large genetic component, with heritability estimated to be between 45% and 70%. Numerous variants have been identified and implicate various molecular mechanisms and pathways for AMD pathogenesis but...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 26467978
DOI: 10.1186/s12859-015-0760-4
PMCID: PMC4606903

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