Article

Rationalize the Functional Roles of Protein-Protein Interactions in Targeted Protein Degradation by Kinetic Monte-Carlo Simulations

2024-09-28

Abstract excerpt

<h4>ABSTRACT</h4> Targeted protein degradation is a promising therapeutic strategy to tackle disease-causing proteins that lack binding pockets for traditional small-molecule inhibitors. Its first step is to trigger the proximity between a ubiquitin ligase complex and a target protein through a heterobifunctional molecule, such as proteolysis targeting chimeras (PROTACs), leading to the formation of a ternary com...

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Literature Corpus work: ab9ae517-4b6d-5939-9357-b8b80c9d3a50
DOI: 10.1101/2024.09.26.615190

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