Article

Coupled feedback loops involving PAGE4, EMT and Notch signaling can give rise to non-genetic heterogeneity in prostate cancer cells

2020-12-30

Abstract excerpt

Non-genetic heterogeneity is emerging to be a crucial factor underlying therapy resistance in multiple cancers. However, the design principles of regulatory networks underlying non-genetic heterogeneity in cancer remain poorly understood. Here, we investigate the coupled dynamics of feedback loops involving a) oscillations in androgen receptor (AR) signaling mediated through an intrinsically disordered protein PAG...

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Literature Corpus work: 34e4020b-9208-540a-ba2b-657988403c93
DOI: 10.1101/2020.12.29.423275

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