Article
Phenotypic plasticity in prostate cancer: role of intrinsically disordered proteins.
Asian journal of andrology - 1 Jan 2000
Mooney Steven M, Jolly Mohit Kumar, Levine Herbert, Kulkarni Prakash
Abstract excerpt
A striking characteristic of cancer cells is their remarkable phenotypic plasticity, which is the ability to switch states or phenotypes in response to environmental fluctuations. Phenotypic changes such as a partial or complete epithelial to mesenchymal transition (EMT) that play important roles in their survival and proliferation, and development of resistance to therapeutic treatments, are widely believed to...
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