Article

Computing tumor specificity of cancer antigen targets by k-mer indexing of healthy tissue transcriptomes

2026-07-03

Abstract excerpt

Individualized cancer immunotherapies rely on tumor-specific T-cell antigens, often predicted from somatic mutations as neoantigens. For tumors with low mutational burden, mRNA transcript variants, including gene fusions and novel splice junctions, can serve as important alternative targets. A main challenge in their identification from tumor RNA-seq is to confirm that their expression is tumor-restricted. Althoug...

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Literature Corpus work: 34d8f11d-c7f5-5c83-a6ff-4e3ca872733d
DOI: 10.64898/2026.06.29.734488

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