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Article

Nodal promotes invasive phenotypes via a mitogen-activated protein kinase-dependent pathway.

Oncogene - 23 Jan 2014

Quail D F, Zhang G, Findlay S D, Hess D A, Postovit L-M

Abstract excerpt

The progression of cancer from localized to invasive disease is requisite for metastasis, and is often characterized by epithelial-to-mesenchymal transition (EMT) and alterations in cellular adhesion and migration. Studies have shown that this transition is associated with an upregulation of embryonic stem cell-associated genes, resulting in a dedifferentiated phenotype and poor patient prognosis. Nodal is an...

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Identifiers

PMID: 23334323
DOI: 10.1038/onc.2012.608
PMCID: PMC5025281

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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