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Detailed phenotyping of <i>Tbr1-2A-CreER</i> knock-in mice demonstrates significant impacts on TBR1 protein levels and axon development

2024-04-04

Abstract excerpt

<h4>ABSTRACT</h4> Spatiotemporal control of Cre-mediated recombination has been an invaluable tool for understanding key developmental processes. For example, knock-in of Cre into cell type marker gene loci drives Cre expression under endogenous promoter and enhancer sequences, greatly facilitating the study of diverse neuronal subtypes in the cerebral cortex. However, insertion of exogenous DNA into the genome...

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Literature Corpus work
345721dd-9092-56d6-844c-7da593803bc2
DOI
10.1101/2024.04.04.588147
Open publication

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Detailed phenotyping of <i>Tbr1-2A-CreER</i> knock-in mice demonstrates significant impacts on TBR1 protein levels and axon developmentDOI 10.1101/2024.04.04.588147
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