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Article

TBR1 regulates autism risk genes in the developing neocortex.

Genome research - 1 Aug 2016

Notwell James H, Heavner Whitney E, Darbandi Siavash Fazel, Katzman Sol, McKenna William L, Ortiz-Londono Christian F, Tastad David, Eckler Matthew J, Rubenstein John L R, McConnell Susan K, Chen Bin, Bejerano Gill

Abstract excerpt

Exome sequencing studies have identified multiple genes harboring de novo loss-of-function (LoF) variants in individuals with autism spectrum disorders (ASD), including TBR1, a master regulator of cortical development. We performed ChIP-seq for TBR1 during mouse cortical neurogenesis and show that TBR1-bound regions are enriched adjacent to ASD genes. ASD genes were also enriched among genes that are...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27325115
DOI: 10.1101/gr.203612.115
PMCID: PMC4971772

Genes

TBR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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