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Article

Early Vasopressor Initiation versus Standard Fluid Resuscitation in Normotensive Cryptic Shock: A Target Trial Emulation

2026-02-03

Abstract excerpt

<title>Abstract</title> <p>Background Current sepsis guidelines mandate aggressive fluid resuscitation prior to vasopressor initiation, primarily targeting hypotension (Mean Arterial Pressure [MAP] < 65 mmHg). However, a distinct phenotype of "Cryptic Shock" characterized by severe tissue hypoperfusion (Lactate > 4.0 mmol/L) despite preserved normotension (MAP > 65 mmHg) remains poorly managed. We hypothesized t...

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Literature Corpus work
34365150-9ab5-519c-8d36-d5958ef4ac6e
DOI
10.21203/rs.3.rs-8747647/v1
Open publication

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Early Vasopressor Initiation versus Standard Fluid Resuscitation in Normotensive Cryptic Shock: A Target Trial EmulationDOI 10.21203/rs.3.rs-8747647/v1
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