Back to search

Article

Comparing the transmission blocking efficacy of Primaquine and Tafenoquine with <i>in vivo</i> pre-clinical models

2026-03-03

Abstract excerpt

The 8-aminoquinoline family are a well-established class of antimalarial drugs containing two clinically relevant analogues, primaquine and tafenoquine. These compounds have two therapeutically significant activities across the plasmodial lifecycle; elimination of Plasmodium vivax hypnozoites as part of a radical cure (relapse prevention), and as prophylactic transmission blocking compounds. Primaquine is current...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
3418376f-771b-58ec-b1f2-3f5a53cbd828
DOI
10.64898/2026.03.03.709295
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Comparing the transmission blocking efficacy of Primaquine and Tafenoquine with <i>in vivo</i> pre-clinical modelsDOI 10.64898/2026.03.03.709295
The transmission blocking activity of artemisinin-combination, non-artemisinin, and 8-aminoquinoline antimalarial therapies: a pooled analysis of individual participant dataSemantic proximity
A <i>Plasmodium vivax</i> controlled human infection and transmission model to evaluate interventions across the life cycleSemantic proximity
New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infectionsSemantic proximity
Adapt or Die: Targeting Unique Transmission-Stage Biology for Malaria EliminationSemantic proximity
Characterizing the pharmacological interaction of the antimalarial combination artefenomel-piperaquine in healthy volunteers with induced blood stage<i>Plasmodium falciparum</i>Semantic proximity
Identifying a next-generation antimalarial trioxolane in a landscape of artemisinin partial resistanceSemantic proximity
A new <i>in vitro</i> checkerboard-parasite reduction ratio interaction assay for early de-risk of clinical development of antimalarial combinationsSemantic proximity
Design and selection of drug properties to increase the public health impact of next-generation seasonal malaria chemoprevention: a modelling studySemantic proximity
A fast-acting inhibitor of blood-stage <i>P. falciparum</i> with mechanism distinct from artemisinin and chloroquineSemantic proximity
Plasmodium vivax: the potential obstacles it presents to malaria elimination and eradicationSemantic proximity
Multistage and transmission-blocking tubulin targeting potent antimalarial discovered from the open access MMV Pathogen BoxSemantic proximity
Establishment and Optimisation of Anti-Babesia microti Drug Efficacy Evaluation MethodSemantic proximity
Select a neighboring publication to make it the new centre.