Article

Single-Cell RNA Sequencing Defines Developmental Progression and Reproductive Transitions of <i>Pneumocystis carinii</i>

2025-04-22

Abstract excerpt

Pneumocystis species are host-obligate fungal pathogens that cause severe pneumonia in immunocompromised individuals. Despite their clinical importance, their life cycle remains poorly understood, in part because Pneumocystis depends on the host environment for most nutrients and requires sexual reproduction for survival, which occurs exclusively in vivo . This study presents the first single-cell RNA sequencing...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 33e516bf-c78a-56be-a706-54edbd009471
DOI: 10.1101/2025.04.21.649879

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-Cell RNA Sequencing Defines Developmental Progression and Reproductive Transitions of <i>Pneumocystis carinii</i>DOI 10.1101/2025.04.21.649879Read

Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hostsSemantic proximity Read

Pathobiology of<i>Pneumocystis</i>pneumonia: life cycle, cell wall and cell signal transductionSemantic proximity Read

<i>De Novo</i> Assembly of the Pneumocystis jirovecii Genome from a Single Bronchoalveolar Lavage Fluid Specimen from a PatientSemantic proximity Read

A Molecular Window into the Biology and Epidemiology of Pneumocystis sppSemantic proximity Read

Comparative Genomics Suggests Primary Homothallism of <i>Pneumocystis</i> SpeciesSemantic proximity Read

Comparative Genomics Suggests that the Fungal Pathogen Pneumocystis Is an Obligate Parasite Scavenging Amino Acids from Its Host's LungsSemantic proximity Read

Transcriptional heterogeneity of <i>Cryptococcus gattii</i> VGII compared with non-VGII lineages underpins key pathogenicity pathwaysSemantic proximity Read

The Dynamics of Cryptococcus neoformans Cell and Transcriptional Remodeling during InfectionSemantic proximity Read

Pneumocystis carinii: genetic diversity and cell biology.Semantic proximity Read

Are Members of the Fungal Genus Pneumocystis (a) Commensals; (b) Opportunists; (c) Pathogens; or (d) All of the Above?Semantic proximity Read

A trade-off between proliferation and defense in the fungal pathogen <i>Cryptococcus</i> at alkaline pH is controlled by the transcription factor GAT201Semantic proximity Read

Analysis of Current Antifungal Agents and Their Targets within the Pneumocystis carinii GenomeSemantic proximity Read