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Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts

22 Feb 2016

Abstract excerpt

Pneumocystis jirovecii is a major cause of life-threatening pneumonia in immunosuppressed patients including transplant recipients and those with HIV/AIDS, yet surprisingly little is known about the biology of this fungal pathogen. Here we report near complete genome assemblies for three Pneumocystis species that infect humans, rats and mice. Pneumocystis genomes are highly compact relative to other fungi, with...

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PMID: 26899007
DOI: 10.1038/ncomms10740

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