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The Dynamics of Cryptococcus neoformans Cell and Transcriptional Remodeling during Infection

2 Dec 2022

Abstract excerpt

The phenotypic plasticity of Cryptococcus neoformans is widely studied and demonstrated in vitro, but its influence on pathogenicity remains unclear. In this study, we investigated the dynamics of cryptococcal cell and transcriptional remodeling during pulmonary infection in a murine model. We showed that in Cryptococcus neoformans, cell size reduction (cell body ≤ 3 µm) is important for initial adaptation during...

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PMID: 36497155
DOI: 10.3390/cells11233896

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