Article

SR-4835, a CDK12 inhibitor, enhances the antitumor efficacy of sunitinib in human renal cell carcinoma through suppression of the ATR-associated DNA damage response pathway: an in vitro and in vivo study

2026-04-17

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> Sunitinib remains an important therapeutic option for advanced renal cell carcinoma (RCC), but intrinsic or acquired resistance substantially limits its clinical benefit. Cyclin-dependent kinase 12 (CDK12) is a transcription-associated kinase that maintains Ser2 phosphorylation of the RNA polymerase II C-terminal domain and supports transcription of genes invo...

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Literature Corpus work: 33bd8875-ee3b-524c-8bab-0b0f54e85b9a
DOI: 10.21203/rs.3.rs-9087369/v1

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