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Article

Sunitinib efficacy with minimal toxicity in patient-derived retinoblastoma organoids

1 Feb 2023

Abstract excerpt

BACKGROUND: Recurrence of retinoblastoma (RB) following chemoreduction is common and is often managed with local (intra-arterial/intravitreal) chemotherapy. However, some tumors are resistant to even local administration of maximum feasible drug dosages, or effective tumor control and globe preservation may be achieved at the cost of vision loss due to drug-induced retinal toxicity. The aim of this study was to...

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PMID: 36726110
DOI: 10.1186/s13046-023-02608-1

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