Article

Genetic and functional analysis of unproductive splicing using LeafCutter2

2025-04-08

Abstract excerpt

Alternative splicing commonly generates unproductive mRNA transcripts that harbor premature termination codons 1 , leading to their degradation by nonsense-mediated decay (NMD). These events reduce overall protein expression levels of affected genes, potentially contributing to gene regulation and disease mechanisms. Here, we present LeafCutter2, which enables identification and quantification of unproductive sp...

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Literature Corpus work: 33ba3921-726d-5940-acc7-ac8c6c329fe9
DOI: 10.1101/2025.04.06.646893

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