Article

LeafCutter: annotation-free quantification of RNA splicing

2016-03-16

Abstract excerpt

The excision of introns from pre-mRNA is an essential step in mRNA processing. We developed LeafCutter to study sample and population variation in intron splicing. LeafCutter identifies variable intron splicing events from short-read RNA-seq data and finds alternative splicing events of high complexity. Our approach obviates the need for transcript annotations and circumvents the challenges in estimating relative...

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Literature Corpus work: 7348c027-d00b-571e-a3e3-c7f8152e28d1
DOI: 10.1101/044107

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