Article

Diverse mediators of cancer predisposition uncovered by germline whole genome sequencing of unexplained familial cancers

2026-05-13

Abstract excerpt

<h4>ABSTRACT</h4> Cancer frequently clusters in families due to shared environment and genetics. However, many familial cancer cases lack a clinically recognized pathogenic germline variant (PGV). We analyzed germline genomes and family history from 2,726 individuals without a PGV in the All of Us Research Program, including 1,496 cases across 18 cancer types with extensive family history and 1,230 family history...

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Literature Corpus work: 33ac69d7-4ddb-56e7-9d5b-e84a3d38a402
DOI: 10.64898/2026.05.08.26352653

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