Article

A shedding analysis after AAV8 CNS injection revealed fragmented viral DNA without evidence of functional AAV particles in mice.

2023-10-24

Abstract excerpt

<title>Abstract</title> <p>Adeno-associated viruses (AAV) are commonly used in the scientific field due to their diverse application range. However, AAV-shedding, the release of virions from the host organism, can impact the safety of AAV-based approaches. An increasing number of authorities require the characterization of vector shedding in clinical trials. Recently, shedding of transduced laboratory animals has...

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Literature Corpus work: 33ab7d54-7566-5189-921e-046230690739
DOI: 10.21203/rs.3.rs-3459293/v1

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