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Article

Evaluation of Risks Related to the Use of Adeno-Associated Virus-Based Vectors

1 Dec 2003

Abstract excerpt

Recombinant AAV efficacy has been demonstrated in numerous gene therapy preclinical studies. As this vector is increasingly applied to human clinical trials, it is a priority to evaluate the risks of its use for workers involved in research and clinical trials as well as for the patients and their descendants. At high multiplicity of infection, wild-type AAV integrates into human chromosome 19 in approximately...

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PMID: 14683451
DOI: 10.2174/1566523034578131

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